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Notch2tm2(cre)Rko
Targeted Allele Detail
Summary
Symbol: Notch2tm2(cre)Rko
Name: notch 2; targeted mutation 2, Raphael Kopan
MGI ID: MGI:5523501
Synonyms: N2::Cre, N2::CreLO
Gene: Notch2  Location: Chr3:97920854-98057683 bp, + strand  Genetic Position: Chr3, 42.42 cM
Alliance: Notch2tm2(cre)Rko page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198632
Parent Cell Line:  B6/BLU (ES Cell)
Strain of Origin:  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Notch2tm2(cre)Rko expression driven by 1 gene
    The intracellular domain (ICD) of Notch2 was replaced with the cre recombinase sequence. (J:172930)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Notch2 (mouse)
Summary of all recombinase alleles driven by Notch2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch2 Mutation:  97 strains or lines available
References
Original:  J:172930 Liu Z, et al., Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS). Genome Res. 2009 Nov;19(11):2081-9
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory