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Tg(Aire-cre/ERT2*)1Mand
Transgene Detail
Summary
Symbol: Tg(Aire-cre/ERT2*)1Mand
Name: transgene insertion 1, Mark Anderson
MGI ID: MGI:5527371
Synonyms: Aire-Cre
Transgene: Tg(Aire-cre/ERT2*)1Mand  Location: unknown  
Alliance: Tg(Aire-cre/ERT2*)1Mand page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tg(Aire-cre/ERT2*)1Mand expression driven by 1 gene
 
Mutation details: A targeting construct was used for recombineering to insert an ERT2-cre-ERT2 sequence (cre fused to two mutated human estrogen receptor ligand-binding domains) into a BAC containing the Aire locus. The inducible cre cassette replaced exon 2 of Aire. The resulting linearized BAC was injected into fertilized FVB oocytes. Founder and line number information is not available. (J:203553)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Aire (species not specified)
Summary of all recombinase alleles driven by Aire.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:203553 Metzger TC, et al., Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013 Oct 17;5(1):166-79
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory