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Xkr8tm1.1Osa
Targeted Allele Detail
Summary
Symbol: Xkr8tm1.1Osa
Name: X-linked Kx blood group related 8; targeted mutation 1.1, Shigekazu Nagata
MGI ID: MGI:5528893
Gene: Xkr8  Location: Chr4:132452208-132459857 bp, - strand  Genetic Position: Chr4, 65.81 cM
Alliance: Xkr8tm1.1Osa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199440
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: An FRT flanked PGK-neo cassette followed by a loxP site was inserted in intron 3 while an additional loxP site was inserted upstream of exon 3. The selection cassette was subsequently excised from properly targeted mice by flp recombinase expression. Exon 3 is thus left flanked by loxP sites. (J:199440)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xkr8 Mutation:  17 strains or lines available
References
Original:  J:199440 Suzuki J, et al., Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science. 2013 Jul 26;341(6144):403-6
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory