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Hcn4tm2.1(cre/ERT2)Sev
Targeted Allele Detail
Summary
Symbol: Hcn4tm2.1(cre/ERT2)Sev
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 2.1, Sylvia Evans
MGI ID: MGI:5529675
Synonyms: HCN4CreERT2
Gene: Hcn4  Location: Chr9:58730695-58770458 bp, + strand  Genetic Position: Chr9, 31.8 cM, cytoband C
Alliance: Hcn4tm2.1(cre/ERT2)Sev page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:204126
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Hcn4tm2.1(cre/ERT2)Sev expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert a CreERT2 coding sequence and frt-flanked neomycin resistance selection cassette immediately before endogenous start codon. The neo cassette was removed by FLP mediated recombination. (J:204126)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hcn4 (mouse)
Summary of all recombinase alleles driven by Hcn4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hcn4 Mutation:  67 strains or lines available
References
Original:  J:204126 Liang X, et al., HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res. 2013 Aug 2;113(4):399-407
All:  8 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory