Gtf2i<tm1Vcam> Targeted Allele Detail MGI Mouse (MGI:5532204)

Gtf2i^tm1Vcam
Targeted Allele Detail

Summary

Symbol:	Gtf2i^tm1Vcam
Name:	general transcription factor II I; targeted mutation 1, Victoria Campuzano
MGI ID:	MGI:5532204
Synonyms:	Gtf2i^deltaexon2
Gene:	Gtf2i Location: Chr5:134266688-134343614 bp, - strand Genetic Position: Chr5, 74.48 cM
Alliance:	Gtf2i^tm1Vcam page

Embryonic abnormalities and craniofacial dysmorphology in Gtf2i^tm1Vcam/Gtf2i^tm1Vcam mutant mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:204278
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A lox511 site and neomycin resistance cassette replaced part of intron 1, exon 2, which contains the ATG translation initiation codon, and part of intron 2. (J:204278)

Generation of the Gtf2i^tm1Vcam allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gtf2i Mutation:	139 strains or lines available

References

Original:	J:204278 Lucena J, et al., Essential role of the N-terminal region of TFII-I in viability and behavior. BMC Med Genet. 2010;11:61
All:	4 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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