Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Kittm1(cre/ERT2)Dsa
Name:	KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1, Dieter Saur
MGI ID:	MGI:5543260
Synonyms:	c-KitCreERT2
Gene:	Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance:	Kittm1(cre/ERT2)Dsa page

Germline Transmission:	Earliest citation of germline transmission: J:204737
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Kittm1(cre/ERT2)Dsa expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Kit (MGI:96677)   Mutation details: A targeting construct with an Frt-flanked neo selection cassette 3' of the cre/ERT2 sequence was used for homologous recombination in ES cells. Cre recombinase was inserted into the ATG site in exon 1 of the Kit locus. Germline transmission of the allele was achieved by crossing to C57BL/J mice. (J:204737)

Activity:	Tissue activity of this recombinase allele
Driver:	Kit (mouse) Summary of all recombinase alleles driven by Kit. Comparative matrix view of recombinase activities Alliance mouse Kit gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

4 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kit Mutation:	182 strains or lines available

Original:	J:204737 Klein S, et al., Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun. 2013;4:1630
All:	32 reference(s)