Cyp11b2<tm1.1(cre)Brlt> Targeted Allele Detail MGI Mouse (MGI:5543601)

Cyp11b2^{tm1.1(cre)Brlt}
Targeted Allele Detail

Summary

Symbol:	Cyp11b2^{tm1.1(cre)Brlt}
Name:	cytochrome P450, family 11, subfamily b, polypeptide 2; targeted mutation 1.1, David T Breault
MGI ID:	MGI:5543601
Synonyms:	AS^Cre
Gene:	Cyp11b2 Location: Chr15:74722859-74728167 bp, - strand Genetic Position: Chr15, 34.29 cM
Alliance:	Cyp11b2^{tm1.1(cre)Brlt} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:204614
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:

Targeted (Recombinase)

Mutations:

Insertion, Intragenic deletion

Cyp11b2^{tm1.1(cre)Brlt} expression driven by 1 gene

Mutation details: A targeting construct with cre recombinase and an Frt-flanked neo cassette was inserted by homologous recombination into the Cyp11b2 (aldosterone synthase, AS) locus, replacing most of the coding region, retaining only exon 1, intron 1 and the first part of exon 2. Germline animals were crossed to Flpe deleter mice to remove the neo cassette. Mice homozygous for the allele are effectrively null for Cyp11b2 function. (J:204614)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cyp11b2 (mouse) Summary of all recombinase alleles driven by Cyp11b2. Alliance mouse Cyp11b2 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cyp11b2 Mutation:	41 strains or lines available

References

Original:	J:204614 Freedman BD, et al., Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30;26(6):666-73
All:	16 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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