Lrrc32tm1.1Hfuj
Targeted Allele Detail
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Symbol: |
Lrrc32tm1.1Hfuj |
Name: |
leucine rich repeat containing 32; targeted mutation 1.1, Hodaka Fujii |
MGI ID: |
MGI:5544317 |
Synonyms: |
GARPfl |
Gene: |
Lrrc32 Location: Chr7:98138515-98151038 bp, + strand Genetic Position: Chr7, 53.86 cM, cytoband E1-F2
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Alliance: |
Lrrc32tm1.1Hfuj page
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Germline Transmission: |
Earliest citation of germline transmission:
J:204761
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Parent Cell Line: |
iTL BA1 (ES Cell)
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Strain of Origin: |
(C57BL/6NTac x 129S6/SvEvTac)F1
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 1. An FRT- and loxP-flanked neomycin resistance cassette was inserted downstream of exon 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 1 floxed.
(J:204761)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NTac * DBA/2 | |
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Phenotypes: |
Affected Systems |
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hematopoietic system
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√
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abnormal regulatory T cell physiology
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√
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immune system
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√
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immune system phenotype
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N
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abnormal regulatory T cell physiology
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:204761 Edwards JP, et al., Regulation of the expression of GARP/latent TGF-beta1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation. J Immunol. 2013 Jun 1;190(11):5506-15 |
All: |
7 reference(s) |
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