Cishtm1.2Cdon
Targeted Allele Detail
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| Symbol: |
Cishtm1.2Cdon |
| Name: |
cytokine inducible SH2-containing protein; targeted mutation 1.2, Chen Dong |
| MGI ID: |
MGI:5544427 |
| Gene: |
Cish Location: Chr9:107173858-107179983 bp, + strand Genetic Position: Chr9, 57.99 cM
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| Alliance: |
Cishtm1.2Cdon page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:204829
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| Parent Cell Line: |
TC1/TC-1 (ES Cell)
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| Strain of Origin: |
129S6/SvEvTac
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT- and loxP-flanked neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted into exon 3 downstream of the coding sequence. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed the coding sequence of exon 2 and 3. Western blot analysis confirmed the absence of protein expression on CD4+ T cells.
(J:204829)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cish Mutation: |
23 strains or lines available
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| Original: |
J:204829 Yang XO, et al., The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nat Immunol. 2013 Jul;14(7):732-40 |
| All: |
2 reference(s) |
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Analysis Tools
