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Spink1tm3(cre)Kymm
Targeted Allele Detail
Summary
Symbol: Spink1tm3(cre)Kymm
Name: serine peptidase inhibitor, Kazal type 1; targeted mutation 3, Ken-ichi Yamamura
MGI ID: MGI:5544431
Synonyms: Spink3cre
Gene: Spink1  Location: Chr18:43861134-43870302 bp, - strand  Genetic Position: Chr18, 23.47 cM, cytoband B3
Alliance: Spink1tm3(cre)Kymm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205182
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Spink1tm3(cre)Kymm expression driven by 1 gene
 
Mutation details: A loxJTZ17 site was inserted at the 5' end of a cassette containing the NLS-cre-polyA sequence (nuclear localization signal-cre recombinase-polyadenylation signal). A PGK-puromycin selection cassett and a lox2272 site was inserted at the 3' end of the targeting construct. Targeted recombination in ES cells already containing Spink3tm1Kymm inserted the cre cassette upstream of exon 1 of Spink3, replacing the neo marker. Chimeras were produced from correctly targeted ES cell clones and germline transmission was established by crosses to C57BL6/J animals. (J:205182)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Spink1 (mouse)
Summary of all recombinase alleles driven by Spink1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spink1 Mutation:  14 strains or lines available
References
Original:  J:205182 Sakata K, et al., Generation and analysis of serine protease inhibitor kazal type 3-cre driver mice. Exp Anim. 2014;63(1):45-53
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory