Tg(Lrat-cre)1Rshw
Transgene Detail
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| Symbol: |
Tg(Lrat-cre)1Rshw |
| Name: |
transgene insertion 1, Robert F Schwabe |
| MGI ID: |
MGI:5545650 |
| Synonyms: |
LratCre |
| Transgene: |
Tg(Lrat-cre)1Rshw Location: unknown
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| Alliance: |
Tg(Lrat-cre)1Rshw page
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| Strain of Origin: |
CBA x C57BL/6J
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Lrat-cre)1Rshw expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Lrat |
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Mutation details: A construct containing a cassette encoding cre recombinase as well as a neo selection cassette was inserted by recombineering methods into a BAC at the ATG codon of the Lrat locus. The neo was removed by arabinose-induced flippase. Purified BAC DNA was injected into pronuclei of fertilized oocytes. Six founders were positive for the transgene and the line with the strongest cre activity in liver and hemotopoietic stem cells was used for further studies.
(J:205330)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Lrat
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:205330 Mederacke I, et al., Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology. Nat Commun. 2013;4:2823 |
| All: |
23 reference(s) |
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Analysis Tools
