Tg(MS4A1-cre/ERT2)1Mjsk
Transgene Detail
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| Symbol: |
Tg(MS4A1-cre/ERT2)1Mjsk |
| Name: |
transgene insertion 1, Mark J Shlomchik |
| MGI ID: |
MGI:5545930 |
| Synonyms: |
hCD20-TamCre, hCD20TamCre |
| Transgene: |
Tg(MS4A1-cre/ERT2)1Mjsk Location: unknown
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| Alliance: |
Tg(MS4A1-cre/ERT2)1Mjsk page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Tg(MS4A1-cre/ERT2)1Mjsk expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| human |
MS4A1 (931) |
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Mutation details: A BAC (RP11-729B4) containing the human MS4A1 (hCD20) locus was modified by insertion of an IRES-cre/ERT2 (cre recombinase-mutated human estrogen receptor ligand-binding domain fusion) cassette into the 3' untranslated region of the gene. The modified BAC vector was used to generate a transgene that expresses a tamoxifen-inducible cre specifically in B cells. MS4A1 is also expressed from this allele. Line numbers are not available.
(J:184524)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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MS4A1
(human)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:184524 Khalil AM, et al., B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science. 2012 Jun 1;336(6085):1178-81 |
| All: |
20 reference(s) |
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Analysis Tools
