Wfikkn2<tm1.1Sjl> Targeted Allele Detail MGI Mouse (MGI:5546173)

Wfikkn2^tm1.1Sjl
Targeted Allele Detail

Summary

Symbol:	Wfikkn2^tm1.1Sjl
Name:	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2; targeted mutation 1.1, Sejin Lee
MGI ID:	MGI:5546173
Synonyms:	Gasp1^-
Gene:	Wfikkn2 Location: Chr11:94126782-94136831 bp, - strand Genetic Position: Chr11, 58.9 cM, cytoband C
Alliance:	Wfikkn2^tm1.1Sjl page

Skeletal muscle abnormalities in Wfikkn2^tm1.1Sjl/Wfikkn2^tm1.1Sjl and Wfikkn1^tm1.1Sjl/Wfikkn1^tm1.1Sjl mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:201148
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. (J:201148)

Generation of the Wfikkn2^tm1.1Sjl allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Wfikkn2 Mutation:	20 strains or lines available

References

Original:	J:201148 Lee YS, et al., Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):E3713-22
All:	1 reference(s)

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