Lat<tm9Mal> Targeted Allele Detail MGI Mouse (MGI:5547536)

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Lat^tm9Mal
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Lat^tm9Mal
Name:	linker for activation of T cells; targeted mutation 9, Bernard Malissen
MGI ID:	MGI:5547536
Synonyms:	Lat(Y136F)
Gene:	Lat Location: Chr7:125962996-125968742 bp, - strand Genetic Position: Chr7, 69.01 cM
Alliance:	Lat^tm9Mal page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:205441
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:		Targeted
Mutations:		Insertion, Nucleotide substitutions
		Mutation details: Nucleotide substitution results in the amino acid substitution of phenylalanine for tyrosine at position 136 (Y136F). (J:205441)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lat Mutation:	10 strains or lines available

References

Original:	J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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