Myod1tm1.1(cre/ERT,TVA)Gcg
Targeted Allele Detail
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| Symbol: |
Myod1tm1.1(cre/ERT,TVA)Gcg |
| Name: |
myogenic differentiation 1; targeted mutation 1.1, Gerard C Grosveld |
| MGI ID: |
MGI:5547828 |
| Synonyms: |
MyoDCE |
| Gene: |
Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
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| Alliance: |
Myod1tm1.1(cre/ERT,TVA)Gcg page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:205518
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| Parent Cell Line: |
F12 (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Inducible, Recombinase) |
| Inducer: |
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tamoxifen |
| Mutation: |
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Insertion
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Myod1tm1.1(cre/ERT,TVA)Gcg expression driven by
1 gene
Knock-in expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Myod1 (MGI:97275) |
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Mutation details: A targeting vector was designed to insert the sequence encoding cre/ERT (CreER), an IRES-TVA (avian leukosis virus receptor) element, a floxed tk-NEO selection cassette, and an IRES sequence into the ATG start codon of the Myod1 gene. The construct was electroporated into "129SvJ" derived F12 embryonic stem (ES) cells, which were transiently transfected with a Cre recombinase vector to remove the selection cassette. ES cells that had successfully undergone cre-mediated recombination and no longer retained the cassette were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6 mice.
(J:205518)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Myod1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:205518 Blum JM, et al., Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. Cell Rep. 2013 Nov 27;5(4):933-40 |
| All: |
1 reference(s) |
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Analysis Tools
