Cd4<tm1(cre/ERT2)Thbu> Targeted Allele Detail MGI Mouse (MGI:5549971)

Cd4^{tm1(cre/ERT2)Thbu}
Targeted Allele Detail

Summary

Symbol:	Cd4^{tm1(cre/ERT2)Thbu}
Name:	CD4 antigen; targeted mutation 1, Thorsten Buch
MGI ID:	MGI:5549971
Synonyms:	CD4-CreER^t2
Gene:	Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
Alliance:	Cd4^{tm1(cre/ERT2)Thbu} page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:204579
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1^a

Mutation
description

Allele Type:

Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Mutations:

Insertion, Intragenic deletion

Cd4^{tm1(cre/ERT2)Thbu} expression driven by 1 gene

Mutation details: A targeting vector was designed to replace part of exon 2 including the ATG codon of the Cd4 locus with the cre/ERT2 fusion gene and Frt-flanked neo marker. Homologous recombination in ES cells generated the knock-in allele. (J:204579)

Generation of Cd4^{tm1(cre/ERT2)Thbu}.

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cd4 (mouse) Summary of all recombinase alleles driven by Cd4. Alliance mouse Cd4 gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cd4 Mutation:	85 strains or lines available

References

Original:	J:204579 Sledzinska A, et al., TGF-beta signalling is required for CD4(+) T cell homeostasis but dispensable for regulatory T cell function. PLoS Biol. 2013 Oct;11(10):e1001674
All:	22 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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