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Gt(ROSA)26Sortm6(cre/ESR1)Arte
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm6(cre/ESR1)Arte
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, TaconicArtemis
MGI ID: MGI:5551323
Synonyms: Gt(ROSA)26Sortm1(cre/ESR1)Arte, Rosa26::CreERT2, rosa(CreERT2)
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm6(cre/ESR1)Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126518
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gt(ROSA)26Sortm6(cre/ESR1)Arte expression driven by 1 gene
 
Mutation details: A fusion protein consisting of cre recombinase and the mutated ligand binding domain of the human estrogen receptor (ERT2) was inserted into intron 1. The estrogen receptor contains 3 mutations (G400V, M543A, L544A) that increase sensitivity to tamoxifen. Following oral administration of tamoxifen recombination efficiency varies from up to 50% to almost 100% depending on the target allele and tissue. Recombination was lowest in the brain. (J:126518)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:126518 Seibler J, et al., Rapid generation of inducible mouse mutants. Nucleic Acids Res. 2003 Feb 15;31(4):e12
All:  16 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
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