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Gdnftm1(cre/ERT2)Cos
Targeted Allele Detail
Summary
Symbol: Gdnftm1(cre/ERT2)Cos
Name: glial cell line derived neurotrophic factor; targeted mutation 1, Frank Costantini
MGI ID: MGI:5553062
Synonyms: GdnfCreERT2
Gene: Gdnf  Location: Chr15:7840327-7867056 bp, + strand  Genetic Position: Chr15, 3.8 cM
Alliance: Gdnftm1(cre/ERT2)Cos page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:206853
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gdnftm1(cre/ERT2)Cos expression driven by 1 gene
 
Mutation details: A targeting vector was designed to insert (from 5' to 3') a glial cell line derived neurotrophic factor (Gdnf) cDNA, an internal ribosomal entry sequence 2 (IRES2), cre/ERT2 coding sequence, an SV40 polyA sequence, and a neomycin selection cassette into exon 2 of the Gdnf gene (J:206853)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gdnf (mouse)
Summary of all recombinase alleles driven by Gdnf.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gdnf Mutation:  19 strains or lines available
References
Original:  J:206853 Cebrian C, et al., The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cell Rep. 2014 Apr 10;7(1):127-37
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory