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Ddx4tm1.1(cre)Dcp
Targeted Allele Detail
Summary
Symbol: Ddx4tm1.1(cre)Dcp
Name: DEAD box helicase 4; targeted mutation 1.1, David C Page
MGI ID: MGI:5554579
Synonyms: Ddx4tm1.1(cre/mOrange)Dcp, MvhCre-mOrange
Gene: Ddx4  Location: Chr13:112734867-112789009 bp, - strand  Genetic Position: Chr13, 63.87 cM
Alliance: Ddx4tm1.1(cre)Dcp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198777
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Ddx4tm1.1(cre)Dcp expression driven by 1 gene
 
Mutation details: The sequence encoding a cre-mOrange fusion protein was inserted into the Ddx4 (Mvh) locus by homologous recombination with a targeting vector in ES cells. Part of exon 1 and intron 1 were replaced by the cre-mOrange sequence. A PGK-neo selection marker was inserted in the initial targeting, and was later removed by mating with FLPe-expressing mice. The mOrange fluorescent reporter in the construct does not appear to be functional. (J:198777)
Generation of Ddx4tm1.1(cre)Dcp
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ddx4 (mouse)
Summary of all recombinase alleles driven by Ddx4.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddx4 Mutation:  59 strains or lines available
References
Original:  J:198777 Hu YC, et al., Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12685-90
All:  12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory