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Wdpcpcys40
Chemically induced Allele Detail
Summary
Symbol: Wdpcpcys40
Name: WD repeat containing planar cell polarity effector; cys40
MGI ID: MGI:5558098
Synonyms: Cys40, Wdpcpm
Gene: Wdpcp  Location: Chr11:21521969-21848686 bp, + strand  Genetic Position: Chr11, 13.9 cM
Alliance: Wdpcpcys40 page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation details: An A to G substitution was detected at nucleotide 224 of the mRNA, corresponding to the 8th base before the splice donor site of exon 5, resulting in a premature stop codon (S54X) after amino acid 54. Homozygous MEFs showed loss of protein immunostaining indicating this is a null allele. (J:94456, J:205269)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wdpcp Mutation:  33 strains or lines available
References
Original:  J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory