Tg(Defa6-icre)1Rsb Transgene Detail MGI Mouse (MGI:5559374)

Tg(Defa6-icre)1Rsb
Transgene Detail

Summary

Symbol:	Tg(Defa6-icre)1Rsb
Name:	transgene insertion 1, Richard S Blumberg
MGI ID:	MGI:5559374
Synonyms:	D6-cre, Defa6-cre
Transgene:	Tg(Defa6-icre)1Rsb Location: unknown
Alliance:	Tg(Defa6-icre)1Rsb page

Transgene
origin

Strain of Origin:

C57BL/6

Transgene
description

Transgene Type:

Transgenic (Recombinase)

Mutation:

Insertion

Tg(Defa6-icre)1Rsb expression driven by 1 gene

Mutation details: Improved cre (icre) cDNA was cloned downstream of the Defa6 promoter in a plasmid construct. A human growth hormone sequence was also present in the construct (Defa6-icre-hGH) which was linearized and used for pronuclear injection. 22 founders were produced and 2 lines were used for further characterization. A representative line was entered. (J:206084)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Defa6 (species not specified) Summary of all recombinase alleles driven by Defa6.

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

Original:	J:206084 Adolph TE, et al., Paneth cells as a site of origin for intestinal inflammation. Nature. 2013 Nov 14;503(7475):272-6
All:	15 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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