PubMed ID MGI Ref. ID | Title | Curated Data | Vol(Iss)Pg | ||||
---|---|---|---|---|---|---|---|
Searching... | |||||||
Hou J; Zhou Y; Zheng Y; Fan J; Zhou W; Ng IO; Sun H; Qin L; Qiu S; Lee JM; Lo CM; Man K; Yang Y; Yang Y; Yang Y; Zhang Q; Zhu X; Li N; Wang Z; Ding G; Zhuang SM; Zheng L; Luo X; Xie Y; Liang A; Wang Z; Zhang M; Xia Q; Liang T; Yu Y; Cao X | Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma. | Cancer Cell | 2014 | 25 (1) 49-63 | 5.592828 | ||
In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-alpha (IFN-alpha) would be very useful in the clinic. We found that expression of retinoic acid-inducible gene-I (RIG-I), an IFN-stimulated gene, was significantly downregulated in human HCC tissues. Patients with low RIG-I expression had shorter survival and poorer response to IFN-alpha therapy, suggesting that RIG-I is a useful prognosis and IFN-alpha response predictor for HCC patients. Mechanistically, RIG-I enhances IFN-alpha response by amplifying IFN-alpha effector signaling via strengthening STAT1 activation. Furthermore, we found that RIG-I deficiency promotes HCC carcinogenesis and that hepatic RIG-I expression is lower in men than in women. RIG-I may therefore be a tumor suppressor in HCC and contribute to HCC gender disparity. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/17/2024 MGI 6.24 |
|
|