About   Help   FAQ
References
Export: Text File
PubMed ID
MGI Ref. ID
Title
Curated Data
Vol(Iss)Pg
Hou J; Zhou Y; Zheng Y; Fan J; Zhou W; Ng IO; Sun H; Qin L; Qiu S; Lee JM; Lo CM; Man K; Yang Y; Yang Y; Yang Y; Zhang Q; Zhu X; Li N; Wang Z; Ding G; Zhuang SM; Zheng L; Luo X; Xie Y; Liang A; Wang Z; Zhang M; Xia Q; Liang T; Yu Y; Cao X
Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma.
  • Functional annotations (GO): 2
  • Genome features: 3
  • Phenotypic alleles: 2
Cancer Cell
2014
25 (1) 49-63
5.592828
In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-alpha (IFN-alpha) would be very useful in the clinic. We found that expression of retinoic acid-inducible gene-I (RIG-I), an IFN-stimulated gene, was significantly downregulated in human HCC tissues. Patients with low RIG-I expression had shorter survival and poorer response to IFN-alpha therapy, suggesting that RIG-I is a useful prognosis and IFN-alpha response predictor for HCC patients. Mechanistically, RIG-I enhances IFN-alpha response by amplifying IFN-alpha effector signaling via strengthening STAT1 activation. Furthermore, we found that RIG-I deficiency promotes HCC carcinogenesis and that hepatic RIG-I expression is lower in men than in women. RIG-I may therefore be a tumor suppressor in HCC and contribute to HCC gender disparity.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/17/2024
MGI 6.24
The Jackson Laboratory