Cd72<c> Allele Detail MGI Mouse (MGI:5563235)

Cd72^c
Allele Detail

Summary

Symbol:	Cd72^c
Name:	CD72 antigen; c haplotype
MGI ID:	MGI:5563235
Gene:	Cd72 Location: Chr4:43447724-43454708 bp, - strand Genetic Position: Chr4, 23.04 cM
Alliance:	Cd72^c page

Mutation
origin

Strain of Origin:

various

Mutation
description

Allele Type:		Not Applicable
Mutation:		Not Applicable
		Mutation details: This serological allele is recognized by epitope 3 (J:8236). Sequence differences between the haplotypes (a, b and c) largely result in amino acid variation in the extracellular domains. The c haplotype contains a 7 amino acid deletion in the C-type lectin-like domain. However, the amino acid sequence of the transmembrane domain and cytoplasmic region is identical to the other hapotype alleles (a, b and d). This allele was identified in the strains AKR, MRL and SJL. (J:1507, J:23623)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Cd72 Mutation:	30 strains or lines available

Notes

The Cd72^c haplotype is a modifier of Fas^lpr-induced autoimmune disease. J:204782

References

Original:	J:1507 Robinson WH, et al., Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72. J Immunol. 1992 Aug 1;149(3):880-6
All:	6 reference(s)

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