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Lhx8tm1(cre)Grsr
Targeted Allele Detail
Summary
Symbol: Lhx8tm1(cre)Grsr
Name: LIM homeobox protein 8; targeted mutation 1, Genetic Resource Science Repository
MGI ID: MGI:5564768
Synonyms: Lhx8cre/cerulean, Lhx8tm1(cre,Cerulean)Grsr
Gene: Lhx8  Location: Chr3:154011925-154036190 bp, - strand  Genetic Position: Chr3, 79.12 cM, cytoband H3-H4
Alliance: Lhx8tm1(cre)Grsr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195615
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Lhx8tm1(cre)Grsr expression driven by 1 gene
 
Mutation details: A targeting vector was designed to replace the stop codon of the endogenous LIM homeobox protein 8 (Lhx8) gene with (from 5' to 3') a viral 2A oligopeptide (to mediate ribosomal skipping), cre recombinase, another 2A oligopeptide, the cerulean variant ofgreen fluorescent protein (GFP), and a bovine polyadenylation sequence. (J:195615)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Lhx8 (mouse)
Summary of all recombinase alleles driven by Lhx8.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lhx8 Mutation:  25 strains or lines available
Notes
The targeting construct was electroporated into C57BL/6NCrl derived JM8A3 embryonic stem (ES) cells. Correctly targeted ES cells were injected into Perfect Host-derived recipient blastocysts and chimeric males were bred with C57BL/6NJ females to establish a colony. Separate Lhx8, cre, and Cerulean transcripts are produced.
References
Original:  J:195615 Genetic Resource Science at The Jackson Laboratory, Alleles generated in the lab of Dr. Steve Murray at The Jackson Laboratory. MGI Direct Data Submission. 2013;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory