Tg(TPO-cre/ERT2)1139Tyj Transgene Detail MGI Mouse (MGI:5565332)

Tg(TPO-cre/ERT2)1139Tyj
Transgene Detail

Summary

Symbol:	Tg(TPO-cre/ERT2)1139Tyj
Name:	transgene insertion 1139, Tyler Jacks
MGI ID:	MGI:5565332
Synonyms:	TPOCreER
Transgene:	Tg(TPO-cre/ERT2)1139Tyj Location: unknown
Alliance:	Tg(TPO-cre/ERT2)1139Tyj page

Transgene
origin

Strain of Origin:

C57BL/6NTac

Transgene
description

Transgene Type:

Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Tg(TPO-cre/ERT2)1139Tyj expression driven by 1 gene

Mutation details: A construct with the human thyroid peroxidase promoter (TPO) and an inducible cre/estrogen receptor ligand-binding domain fusion (cre/ERT2) was used to generate transgenic founders. Two founders were obtained and one (#1139) was used for further analyses. (J:208854)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	TPO (human) Summary of all recombinase alleles driven by TPO. Alliance human TPO gene page

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Tumor Data

List all tumor models in MMHCdb carrying Tg(TPO-cre/ERT2)1139Tyj

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

Original:	J:208854 McFadden DG, et al., p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):E1600-9
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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