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Gt(ROSA)26Sortm1(cre/Esr1*)Nns
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(cre/Esr1*)Nns
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Nicholas N Smithers
MGI ID: MGI:5566525
Synonyms: RMCM, Rosa26MerCreMer
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(cre/Esr1*)Nns page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194830
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(cre/Esr1*)Nns expression driven by 1 gene
 
Mutation details: cDNA encoding a cre/Esr1* fusion protein (MerCreMer; cre fused to 2 mutated mouse estrogen receptor ligand binding domains) was inserted into the Gt(ROSA)26Sor locus. Details are unpublished. (J:194830)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor (mouse)
Summary of all recombinase alleles driven by Gt(ROSA)26Sor.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  993 strains or lines available
References
Original:  J:194830 Schweighoffer E, et al., The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway. Immunity. 2013 Mar 21;38(3):475-88
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory