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Npr2tm2.1(cre/ERT2)Fgr
Targeted Allele Detail
Summary
Symbol: Npr2tm2.1(cre/ERT2)Fgr
Name: natriuretic peptide receptor 2; targeted mutation 2.1, Fritz G Rathjen
MGI ID: MGI:5567995
Synonyms: Npr2-CreERT2
Gene: Npr2  Location: Chr4:43631935-43651244 bp, + strand  Genetic Position: Chr4, 23.05 cM
Alliance: Npr2tm2.1(cre/ERT2)Fgr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205571
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Npr2tm2.1(cre/ERT2)Fgr expression driven by 1 gene
 
Mutation details: A targeting construct was used to replace exon 1 of the Npr2 gene with the sequence for a tamoxifen- inducible cre recombinase (cre/ERT2) followed by a polyadenylation signal and an frt-flanked neo selection marker, by homologous recombination in ES cells. The neo marker was deleted by crossbreeding with Flp-expressing mice. (J:205571)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Npr2 (mouse)
Summary of all recombinase alleles driven by Npr2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npr2 Mutation:  63 strains or lines available
References
Original:  J:205571 Ter-Avetisyan G, et al., Bifurcation of Axons from Cranial Sensory Neurons Is Disabled in the Absence of Npr2-Induced cGMP Signaling. J Neurosci. 2014 Jan 15;34(3):737-47
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory