Tg(Gata1-icre)1Jtp
Transgene Detail
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| Symbol: |
Tg(Gata1-icre)1Jtp |
| Name: |
transgene insertion 1, Josef T Prchal |
| MGI ID: |
MGI:5568218 |
| Synonyms: |
Gata-1-HRD-iCre |
| Transgene: |
Tg(Gata1-icre)1Jtp Location: unknown
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| Alliance: |
Tg(Gata1-icre)1Jtp page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Gata1-icre)1Jtp expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| Not Specified |
Gata1 |
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Mutation details: A construct was generated by inserting the icre (improved cre) cDNA between the promoter region and polyA site in the IE3.9intpolyAA construct (containg the Gata1-HRD promoter (HRD; hematopoietic regulatory domain)). The transgenic vector was verified by sequencing, linearized and used for pronuclear injection. Three transgenic founders were identified from 16 chimeras, and cre activity was assessed in progeny of crossed to ROSA26 reporter animals. Reporter activation was detected only in bone marrow cells (in early erythroid progenitors) and not in any other organ or tissue examined. The line with greatest cre activity was selected for further analyses.
(J:209268)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Gata1
(species not specified)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:209268 Yoon D, et al., Cre recombinase expression controlled by the hematopoietic regulatory domain of Gata-1 is erythroid-specific. Blood Cells Mol Dis. 2008 May-Jun;40(3):381-7 |
| All: |
1 reference(s) |
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Analysis Tools
