Med23<tm1.1Pkb> Targeted Allele Detail MGI Mouse (MGI:5568337)

Med23^tm1.1Pkb
Targeted Allele Detail

Summary

Symbol:	Med23^tm1.1Pkb
Name:	mediator complex subunit 23; targeted mutation 1.1, Paul K Brindle
MGI ID:	MGI:5568337
Synonyms:	Med23^flox
Gene:	Med23 Location: Chr10:24745889-24789358 bp, + strand Genetic Position: Chr10, Syntenic
Alliance:	Med23^tm1.1Pkb page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Mutation
description

Allele Type:		Targeted (Conditional ready)
Mutation:		Insertion
		Mutation details: An FRT-flanked neomycin cassette was placed in intron 4 and exons 5-7 of the gene were flanked by loxP sites. Transient expression of FLP recombinase in the ES cells excised the neomycin cassette, leaving floxed exons 5-7. (J:217860)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Med23 Mutation:	75 strains or lines available

Notes

The version of this allele that does not contain the neomycin selection cassette, Med23^tm1Pkb, has been analyzed.

References

Original:	J:217860 Kasper LH, et al., T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One. 2014;9(7):e102076
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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