Setd1a<tm1Afst> Targeted Allele Detail MGI Mouse (MGI:5568936)

Setd1a^tm1Afst
Targeted Allele Detail

Summary

Symbol:	Setd1a^tm1Afst
Name:	SET domain containing 1A; targeted mutation 1, A Francis Stewart
MGI ID:	MGI:5568936
Synonyms:	Setd1a^A
Gene:	Setd1a Location: Chr7:127376561-127399294 bp, + strand Genetic Position: Chr7, 69.73 cM
Alliance:	Setd1a^tm1Afst page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:208420
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:		Insertion
		Mutation details: : An FRT-flanked stop cassette containing a reporter, followed by loxP-flanked exon 4 was inserted. Immuno-staining confirmed loss of protein at E6.5 and E7.5. (J:208420)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Setd1a Mutation:	57 strains or lines available

References

Original:	J:208420 Bledau AS, et al., The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation. Development. 2014 Mar;141(5):1022-35
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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