About   Help   FAQ
Tas2r131tm2.1(cre)Uboe
Targeted Allele Detail
Summary
Symbol: Tas2r131tm2.1(cre)Uboe
Name: taste receptor, type 2, member 131; targeted mutation 2.1, Ulrich Boehm
MGI ID: MGI:5569285
Synonyms: Tas2r131BLiC, Tas2r131F/MBLF/M-IRES-Cre
Gene: Tas2r131  Location: Chr6:132933875-132934807 bp, - strand  Genetic Position: Chr6, 64.03 cM
Alliance: Tas2r131tm2.1(cre)Uboe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200616
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Epitope tag, Null/knockout, Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Tas2r131tm2.1(cre)Uboe expression driven by 1 gene
 
Mutation details: The Tas2r131 coding region was replaced with an expression cassette encoding the barley lectin (BL) sequence linked through an internal ribosome entry cassette to the cre recombinase sequence. Both flag and c-myc epitopes (for differential transsynaptic tracing) were inserted into the BL sequence at positions 79 and 597. An AFN (tACE-Flpe/NEOr) neomycin selection cassette, flanked by FRT sites was also inserted. The neomycin selection cassette was removed by crossing to Flpe-deleter. This allele is a Tas2r131 null and produces a bicistronic transcript BL and cre from the Tas2r131 promoter. (J:200616, J:209852, J:309106)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tas2r131 (mouse)
Summary of all recombinase alleles driven by Tas2r131.
 

Expression
In Mice Carrying this Mutation: 83 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tas2r131 Mutation:  20 strains or lines available
References
Original:  J:200616 Foster SR, et al., Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS One. 2013;8(5):e64579
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory