Tg(Dmp1-cre)1Btm
Transgene Detail
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| Symbol: |
Tg(Dmp1-cre)1Btm |
| Name: |
transgene insertion 1, Teresita M Bellido |
| MGI ID: |
MGI:5570152 |
| Synonyms: |
DMP1-8kb-Cre |
| Transgene: |
Tg(Dmp1-cre)1Btm Location: unknown
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| Alliance: |
Tg(Dmp1-cre)1Btm page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Dmp1-cre)1Btm expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Dmp1 (MGI:94910) |
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Mutation details: This transgene contains the cre recombinase coding sequence downstream of a 12-kb DNA fragment from the mouse dentin matrix protein 1 (Dmp1) gene containing ~8 kb of 5' flanking sequence, the first exon, the first intron and 17 bp of exon 2. Cre recombinase transcripts are detected in bone of 1-month-old transgenic mice, but not in brain, heart, kidney or skeletal muscle. However, deletion of a loxP-flanked sequence is observed at low levels in brain. RT-PCR analysis of FACS-sorted calvarial cells from neonatal transgenic mice revealed the presence of cre recombinase transcripts only in cells containing high levels of mRNA encoding the osteocyte marker sclerostin (SOST) and low levels of the osteoblast marker keratocan.
(J:210294)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Dmp1
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:210294 Bivi N, et al., Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. J Bone Miner Res. 2012 Feb;27(2):374-89 |
| All: |
22 reference(s) |
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Analysis Tools
