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Kittm1.1(cre)Jmol
Targeted Allele Detail
Summary
Symbol: Kittm1.1(cre)Jmol
Name: KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1.1, Jeffery D Molkentin
MGI ID: MGI:5571474
Synonyms: KitCre
Gene: Kit  Location: Chr5:75735647-75817382 bp, + strand  Genetic Position: Chr5, 39.55 cM
Alliance: Kittm1.1(cre)Jmol page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210584
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Kittm1.1(cre)Jmol expression driven by 1 gene
 
Mutation details: A cDNA encoding a cre-IRES-nlsEGFP (cre recombinase separated by an internal ribosomal entry site from the nuclear localized EGFP coding sequence) cassette and an frt-flanked neomycin selection marker were cloned in-frame at the Kit ATG start site in exon 1. Homologous recombination was performed in ES cells which were aggregated with 8-cell embryos to generate chimeras. Chimeras were crossed to knock-in flp-expressing mice to delete the neo marker. Animals produce a bicistronic transcript for production of cre and EGFP proteins. (J:101977, J:210584)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Kit (mouse)
Summary of all recombinase alleles driven by Kit.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 21 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kit Mutation:  182 strains or lines available
References
Original:  J:210584 van Berlo JH, et al., c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014 May 15;509(7500):337-41
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory