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Atp1a3tm1.1Kwk
Targeted Allele Detail
Summary
Symbol: Atp1a3tm1.1Kwk
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide; targeted mutation 1.1, Kiyoshi Kawakami
MGI ID: MGI:5572809
Gene: Atp1a3  Location: Chr7:24677592-24705338 bp, - strand  Genetic Position: Chr7, 13.73 cM
Alliance: Atp1a3tm1.1Kwk page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210870
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 2 through 6 were replaced with a loxP site, the cDNA fused to EGFP, an FRT-flanked neomycin resistance cassette, a loxP site and STOP/polyadenylation cassette. Cre-mediated recombination removed the fusion cDNA and selection cassette. (J:210870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp1a3 Mutation:  70 strains or lines available
References
Original:  J:210870 Ikeda K, et al., Enhanced inhibitory neurotransmission in the cerebellar cortex of Atp1a3-deficient heterozygous mice. J Physiol. 2013 Jul 1;591(Pt 13):3433-49
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory