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Piezo2tm1.1(cre)Apat
Targeted Allele Detail
Summary
Symbol: Piezo2tm1.1(cre)Apat
Name: piezo-type mechanosensitive ion channel component 2; targeted mutation 1.1, Ardem Patapoutian
MGI ID: MGI:5574478
Synonyms: Piezo2-EGFP-IRES-Cre, Piezo2GFP
Gene: Piezo2  Location: Chr18:63143284-63520254 bp, - strand  Genetic Position: Chr18, 35.95 cM, cytoband D3
Alliance: Piezo2tm1.1(cre)Apat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211312
Parent Cell Line:  C2 (Nagy) (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Piezo2tm1.1(cre)Apat expression driven by 1 gene
 
Mutation details: An EGFP-IRES-cre cassette followed by an FRT-flanked neomycin resistance selection cassette and loxP site were inserted at the end of exon 54. Flp-mediated recombination removed the selection cassette. (J:211312)
Inheritance:    Not Specified
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Piezo2 (mouse)
Summary of all recombinase alleles driven by Piezo2.
 

Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Piezo2 Mutation:  123 strains or lines available
References
Original:  J:211312 Woo SH, et al., Piezo2 is required for Merkel-cell mechanotransduction. Nature. 2014 May 29;509(7502):622-6
All:  35 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory