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Tbx21tm1.1(flpe/ERT2)Gmld
Targeted Allele Detail
Summary
Symbol: Tbx21tm1.1(flpe/ERT2)Gmld
Name: T-box 21; targeted mutation 1.1, Graham M Lord
MGI ID: MGI:5575639
Synonyms: T-betfl
Gene: Tbx21  Location: Chr11:96988897-97006157 bp, - strand  Genetic Position: Chr11, 60.95 cM, cytoband D
Alliance: Tbx21tm1.1(flpe/ERT2)Gmld page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207104
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tbx21tm1.1(flpe/ERT2)Gmld expression driven by 1 gene
 
Mutation details: A loxP site was inserted upstream of exon 4. An IRES, flpeERT2, polyadenylation sequence, FRT-flanked neomycin resistance cassette and a loxP site were inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exons 4 through 6 floxed. (J:207104)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tbx21 (mouse)
Summary of all recombinase alleles driven by Tbx21.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx21 Mutation:  39 strains or lines available
References
Original:  J:207104 Gokmen MR, et al., Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol. 2013 Dec 15;191(12):5925-32
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory