Tmem127tm1.1Pdah
Targeted Allele Detail
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| Symbol: |
Tmem127tm1.1Pdah |
| Name: |
transmembrane protein 127; targeted mutation 1.1, Patricia Dahia |
| MGI ID: |
MGI:5581337 |
| Synonyms: |
Tmem127null |
| Gene: |
Tmem127 Location: Chr2:127089868-127103028 bp, + strand Genetic Position: Chr2, 61.87 cM
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| Alliance: |
Tmem127tm1.1Pdah page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:209071
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| Parent Cell Line: |
Bruce 4 (ES Cell)
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| Strain of Origin: |
B6.Cg-Thy1a
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: LoxP sites were inserted in introns 2 and 4, with an IRES-GFP cassette inserted after the stop codon in exon 4. Cre-mediated recombination removed exons 3 and 4. Western analysis of mouse embryonic fibroblasts showed an absent of protein expression.
(J:209071)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tmem127 Mutation: |
16 strains or lines available
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| Original: |
J:209071 Qin Y, et al., The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. Hum Mol Genet. 2014 May 1;23(9):2428-39 |
| All: |
2 reference(s) |
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Analysis Tools
