Tg(Cryaa-cre,Tyr)37Mlr
Transgene Detail
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| Symbol: |
Tg(Cryaa-cre,Tyr)37Mlr |
| Name: |
transgene insertion 37, Mike Robinson |
| MGI ID: |
MGI:5582797 |
| Synonyms: |
CPV2/Cre, MLR37 |
| Transgene: |
Tg(Cryaa-cre,Tyr)37Mlr Location: unknown
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| Alliance: |
Tg(Cryaa-cre,Tyr)37Mlr page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(Cryaa-cre,Tyr)37Mlr expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Note |
| mouse |
Cryaa (MGI:88515) |
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Mutation details: The mouse alpha A crystallin promoter (nucleotides -282 through +43 of the Cryaa gene) drives expression of the cre recombinase coding sequence, which is followed by the intron and polyadenylation signal of the mouse metallothionein 1 gene. Seven founder lines were generated using this construct, which in this line was coinjected with a tyrosinase minigene. In transgenic mice of this line also carrying Gt(ROSA)26Sortm1Sor, X-Gal staining for beta-galactosidase activity demonstrates low level cre recombinase expression in lens epithelium and higher level expression in lens fiber cells; ectopic ocular expression is observed in the retina, retinal pigmented epithelium (RPE) and cornea.
(J:90292)
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| Inheritance: |
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Dominant |
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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Cryaa
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:90292 Zhao H, et al., Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1930-9 |
| All: |
1 reference(s) |
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Analysis Tools
