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Flt4tm2.1(cre/Esr1*)Ichi
Targeted Allele Detail
Summary
Symbol: Flt4tm2.1(cre/Esr1*)Ichi
Name: FMS-like tyrosine kinase 4; targeted mutation 2.1, Hirotake Ichise
MGI ID: MGI:5584320
Synonyms: Vegfr3-CreMer
Gene: Flt4  Location: Chr11:49500506-49543566 bp, + strand  Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
Alliance: Flt4tm2.1(cre/Esr1*)Ichi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212356
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6J x 129S/SvEv)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Flt4tm2.1(cre/Esr1*)Ichi expression driven by 1 gene
 
Mutation details: The coding sequence in the first exon was replaced with a fusion of cre and tamoxifen-inducible cre recombinase (Cremer) followed by an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:212356)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Flt4 (mouse)
Summary of all recombinase alleles driven by Flt4.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Flt4 Mutation:  77 strains or lines available
References
Original:  J:212356 Ichise T, et al., FGF2-induced Ras-MAPK signalling maintains lymphatic endothelial cell identity by upregulating endothelial-cell-specific gene expression and suppressing TGFbeta signalling through Smad2. J Cell Sci. 2014 Feb 15;127(Pt 4):845-57
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
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