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Hand1tm3Abfi
Targeted Allele Detail
Summary
Symbol: Hand1tm3Abfi
Name: heart and neural crest derivatives expressed 1; targeted mutation 3, Anthony B Firulli
MGI ID: MGI:5604130
Synonyms: Hand1stopfloxHand1T107;S109A, PO4-
Gene: Hand1  Location: Chr11:57719539-57722973 bp, - strand  Genetic Position: Chr11, 35.27 cM
Alliance: Hand1tm3Abfi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214092
Parent Cell Line:  CCE916 (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation details: Residues T107 and S109 were replaced with alanines. A Stop-flox cassette containing a neomycin resistance gene was also inserted downstream of the Hand1 transcriptional start site, but upstream of the Hand1-initiating methionine. Cre-excision of the stop cassette results in expression of the mutant. (J:214092)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hand1 Mutation:  15 strains or lines available
References
Original:  J:214092 Firulli BA, et al., Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug;141(15):3050-61
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory