Hand1tm4Abfi
Targeted Allele Detail
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| Symbol: |
Hand1tm4Abfi |
| Name: |
heart and neural crest derivatives expressed 1; targeted mutation 4, Anthony B Firulli |
| MGI ID: |
MGI:5604131 |
| Synonyms: |
Hand1stopfloxHand1T107;S109D, PO4+ |
| Gene: |
Hand1 Location: Chr11:57719539-57722973 bp, - strand Genetic Position: Chr11, 35.27 cM
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| Alliance: |
Hand1tm4Abfi page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:214092
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| Parent Cell Line: |
CCE916 (ES Cell)
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| Strain of Origin: |
129S/SvEv
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| Allele Type: |
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Targeted (Conditional ready) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Residues T107 and S109 were replaced with aspartic acids. A Stop-flox cassette containing a neomycin resistance gene was also inserted downstream of the Hand1 transcriptional start site, but upstream of the Hand1-initiating methionine. Cre-excision of the stop cassette results in expression of the mutant.
(J:214092)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Hand1 Mutation: |
15 strains or lines available
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| Original: |
J:214092 Firulli BA, et al., Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development. 2014 Aug;141(15):3050-61 |
| All: |
2 reference(s) |
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Analysis Tools
