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Kcnq3tm1.1Avtz
Targeted Allele Detail
Summary
Symbol: Kcnq3tm1.1Avtz
Name: potassium voltage-gated channel, subfamily Q, member 3; targeted mutation 1.1, Anastasios V Tzingounis
MGI ID: MGI:5607736
Synonyms: Kcnq3fl
Gene: Kcnq3  Location: Chr15:65858236-66158491 bp, - strand  Genetic Position: Chr15, 29.16 cM
Alliance: Kcnq3tm1.1Avtz page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:208109
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (C57BL/6J x 129/Sv)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: Exons 2-4 were floxed and an FRT flanked neomycin cassette was inserted via homologous recombination. Flp mediated recombination removed the neomycin cassette. (J:208109)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnq3 Mutation:  48 strains or lines available
References
Original:  J:208109 Soh H, et al., Conditional Deletions of Epilepsy-Associated KCNQ2 and KCNQ3 Channels from Cerebral Cortex Cause Differential Effects on Neuronal Excitability. J Neurosci. 2014 Apr 9;34(15):5311-21
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory