Semg1<tm1Kemi> Targeted Allele Detail MGI Mouse (MGI:5607932)

Semg1^tm1Kemi
Targeted Allele Detail

Summary

Symbol:	Semg1^tm1Kemi
Name:	semenogelin 1; targeted mutation 1, Kenji Miyado
MGI ID:	MGI:5607932
Gene:	Semg1 Location: Chr2:164077849-164080261 bp, - strand Genetic Position: Chr2, 84.82 cM
Alliance:	Semg1^tm1Kemi page

Seminal vesicle appearance and absence of copulatory plugs in Semg1^tm1Kemi/Semg1^tm1Kemi and Semg1^tm2Kemi/Semg1^tm2Kemi mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:207389
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6N

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neo cassette replaced all 3 exons via homologous recombination. Absence of protein expression was confirmed by SDS/PAGE analysis using total proteins from seminal vesicles. (J:207389)

Generation of the Semg1^tm1Kemi allele

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Semg1 Mutation:	30 strains or lines available

Notes

In J:207389 the alleles Svs2^tm1Kemi and Svs2^tm2Kemi were reported to give the same results and data were pooled for both alleles.

References

Original:	J:207389 Kawano N, et al., Seminal vesicle protein SVS2 is required for sperm survival in the uterus. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4145-50
All:	3 reference(s)

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