Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ins1tm1.1(cre)Thor
Name:	insulin I; targeted mutation 1.1, Bernard Thorens
MGI ID:	MGI:5614359
Synonyms:	Ins1Cre
Gene:	Ins1  Location: Chr19:52252735-52253453 bp, + strand  Genetic Position: Chr19, 46.76 cM
Alliance:	Ins1tm1.1(cre)Thor page

Germline Transmission:	Earliest citation of germline transmission: J:217521
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout, Recombinase) Mutations:    Insertion, Intragenic deletion   Ins1tm1.1(cre)Thor expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Ins1 (MGI:96572)   Mutation details: A targeting construct was designed to insert a cre recombinase gene at the initiation codon of the gene with followed by a FRT-flanked neomycin resistance (neo) cassette, replacing the coding sequence. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:217521)

Activity:	Tissue activity of this recombinase allele
Driver:	Ins1 (mouse) Summary of all recombinase alleles driven by Ins1. Comparative matrix view of recombinase activities Alliance mouse Ins1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

8 assay results 2 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Ins1tm1.1(cre)Thor

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ins1 Mutation:	46 strains or lines available

Original:	J:217521 Thorens B, et al., Ins1(Cre) knock-in mice for beta cell-specific gene recombination. Diabetologia. 2015 Mar;58(3):558-65
All:	76 reference(s)