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Ntrk2tm3.1(cre/ERT2)Ddg
Targeted Allele Detail
Summary
Symbol: Ntrk2tm3.1(cre/ERT2)Ddg
Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 3.1, David D Ginty
MGI ID: MGI:5616440
Synonyms: TrkBCreER, TrkB-CreERT2, TrkBCreERT2
Gene: Ntrk2  Location: Chr13:58954383-59281784 bp, + strand  Genetic Position: Chr13, 31.2 cM
Alliance: Ntrk2tm3.1(cre/ERT2)Ddg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:192549
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Ntrk2tm3.1(cre/ERT2)Ddg expression driven by 1 gene
 
Mutation details: A Cre recombinase-estrogen receptor T2 (CreERT2) fusion-FRT-Neomycin-FRT-loxP cassette was introduced into the first coding ATG of exon 2. All 212 bp of exon 2 (encoding the first 70 amino acids containing entire signal peptide) were replaced. (J:192549, J:218012)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ntrk2 (mouse)
Summary of all recombinase alleles driven by Ntrk2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk2 Mutation:  66 strains or lines available
References
Original:  J:192549 Liu Y, et al., Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. Science. 2012 Dec 7;338(6112):1357-60
All:  29 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory