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Cdh5tm7Dvst
Targeted Allele Detail
Summary
Symbol: Cdh5tm7Dvst
Name: cadherin 5; targeted mutation 7, Dietmar Vestweber
MGI ID: MGI:5621267
Synonyms: VECdelta75
Gene: Cdh5  Location: Chr8:104828257-104871143 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance: Cdh5tm7Dvst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:213676
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsRMCE using Cdh5tm1Dvst replaced exon 2 and the neomycin resistance cassette with a cDNA lacking the coding sequence for the C-terminal 75 amino acids (VECdelta75), a transcriptional stop site and a hygromycin resistance cassette. (J:213676)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh5 Mutation:  59 strains or lines available
Notes
This allele was generated from Cdh5tm1Dvst.
References
Original:  J:213676 Dartsch N, et al., Fusing VE-cadherin to alpha-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation. Mol Cell Biol. 2014 May;34(9):1634-48
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory