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Mir34atm2.1Hher
Targeted Allele Detail
Summary
Symbol: Mir34atm2.1Hher
Name: microRNA 34a; targeted mutation 2.1, Heiko Hermeking
MGI ID: MGI:5629848
Synonyms: mir-34aloxP
Gene: Mir34a  Location: Chr4:150152911-150153012 bp, + strand  Genetic Position: Chr4, 80.85 cM
Alliance: Mir34atm2.1Hher page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:175978
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation details: A loxP site was inserted upstream of the microRNA. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of the microRNA. Flp-mediated recombination remoced the selection cassette and left the microRNA floxed. This allele was used to generate Mir34atm1Hher. (J:175978)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir34a Mutation:  9 strains or lines available
References
Original:  J:175978 Hwang CI, et al., Wild-type p53 controls cell motility and invasion by dual regulation of MET expression. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14240-5
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory