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Il22tm1.1(icre)Stck
Targeted Allele Detail
Summary
Symbol: Il22tm1.1(icre)Stck
Name: interleukin 22; targeted mutation 1.1, Brigitta Stockinger
MGI ID: MGI:5632146
Synonyms: IL22Cre
Gene: Il22  Location: Chr10:118040847-118045952 bp, + strand  Genetic Position: Chr10, 66.67 cM
Alliance: Il22tm1.1(icre)Stck page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220074
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Il22tm1.1(icre)Stck expression driven by 1 gene
 
Mutation details: A targeting construct was designed to replace exon 1 of the Il22 (interleukin 22) gene with a 6 aa linker sequence, a codon improved Cre Recombinase gene (iCre) followed by an SV40 polyadenylation sequence and a FRT-flanked neomycin resistance (neo) cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:220074)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Il22 (mouse)
Summary of all recombinase alleles driven by Il22.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il22 Mutation:  29 strains or lines available
References
Original:  J:220074 Ahlfors H, et al., IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection. J Immunol. 2014 Nov 1;193(9):4602-13
All:  18 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory