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Acantm1.1(EGFP/cre/ERT2)Wtsi
Targeted Allele Detail
Summary
Symbol: Acantm1.1(EGFP/cre/ERT2)Wtsi
Name: aggrecan; targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI ID: MGI:5632381
Synonyms: Acantm1.1(EGFP/cre/ERT2)Hmgu
Gene: Acan  Location: Chr7:78703231-78764847 bp, + strand  Genetic Position: Chr7, 44.88 cM
Alliance: Acantm1.1(EGFP/cre/ERT2)Wtsi page
Mutation
origin
Mutant Cell Line:  CEPD0018_4_B02
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMMTOOLS
Mutation
description
Allele Type:    Targeted (Conditional ready, Inducible, Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Acantm1.1(EGFP/cre/ERT2)Wtsi expression driven by 1 gene
 
Mutation details: According to the allele molecular image presented by the International Knockout Mouse Consortium, this allele has loxP sites flanking exon 4, and inserted into the intron between exons 3 and 4 is one FRT site, an engrailed 2 splice acceptor sequence, an EGFP and cre/ERT2 expression cassette, and a single Rox site remaining after a flanked puromycin resistance cassette removal. (J:155845)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Acan (mouse)
Summary of all recombinase alleles driven by Acan.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acan Mutation:  80 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory