Fosbtm3.1Yun
Targeted Allele Detail
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| Symbol: |
Fosbtm3.1Yun |
| Name: |
FBJ osteosarcoma oncogene B; targeted mutation 3.1, Yusaku Nakabeppu |
| MGI ID: |
MGI:5634958 |
| Synonyms: |
fosBF |
| Gene: |
Fosb Location: Chr7:19036621-19043970 bp, - strand Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
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| Alliance: |
Fosbtm3.1Yun page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:211298
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| Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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| Strain of Origin: |
129S/SvEv-Gpi1c
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| Allele Type: |
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Targeted (Modified isoform(s)) |
| Mutation: |
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Nucleotide substitutions
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Mutation details: Three bases (GAGGTGAGA->GAAGTTCGA) in the alternative splicing donor site and two bases (AGTGAA->TCTGAA) in the splice acceptor site were modified via homologous recombination to prevent expression of the long transcript while retaining expression of the shorter transcript. A floxed neo cassette was also inserted in intron 3. Cre mediated recombination removed the neo cassette. This allele lacks expression of the deltaFosb isoform.
(J:220449)
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| Original: |
J:220449 Ohnishi YN, et al., Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell. 2008 Nov;19(11):4717-29 |
| All: |
2 reference(s) |
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Analysis Tools
